PRIMA-1MET

Alternative_name

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one; APR-246
Description

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 2170). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.
CAS Number

5291-32-7
Structure Available

Yes
Molecular Formula

C₁₀H₁₇NO₃
Molecular Weight

199.25
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>15 mg/ml) or H₂O (>15 mg/ml)
Handling

Protect from air and light
Tag Line

Mutant p53 activator
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

36 months
MDL Number

MFCD16294187
PubChem CID

52918385
PubChem CID Link
SMILES

COCC1(C(=O)C2CCN1CC2)CO
InChi

InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3
InChi Key

BGBNULCRKBVAKL-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes