Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha, HNF4alpha, HNF-4-alpha, HNF4a, HNF4, FLJ39654, MODY, MODY1, Nuclear Receptor Subfamily 2 Group A Member 1, NR2A1, NR2A21, Transcription Factor 14, TCF14, TCF-14, Transcription Factor HNF-4)

• Catalog number
  MBS621334
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [Hepatocyte Nuclear Factor 4 alpha]
• Products_name_syn
  [Anti -Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha, HNF4alpha, HNF-4-alpha, HNF4a, HNF4, FLJ39654, MODY, MODY1, Nuclear Receptor Subfamily 2 Group A Member 1, NR2A1, NR2A21, Transcription Factor 14, TCF14, TCF-14, Transcription Factor HNF-4)]
• Other_names
  [hepatocyte nuclear factor 4-alpha isoform d; Hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4-alpha; TCF-14; HNF-4-alpha; HNF4alpha10/11/12; OTTHUMP00000031059; OTTHUMP00000031060; OTTHUMP00000031062; transcription factor 14; transcription factor-14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4 4 alpha variant 1; hepatocyte nuclear factor 4 4 alpha variant 2; hepatocyte nuclear factor 4 4 alpha variant 4; nuclear receptor subfamily 2 group A member 1; hepatocyte nuclear factor 4, alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4]
• Other_gene_names
  [HNF4A; HNF4A; TCF; HNF4; MODY; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; FLJ39654; HNF4alpha; HNF4; NR2A1; TCF14]
• Clonality
  Polyclonal
• Reactivity
  Human
• Specificity
  Recognizes human HNF4A.
• Purity
  Affinity Purified Purified by Protein A afinity chromatography.
• Form
  Supplied as a liquid in PBS, 0.09% sodium azide.
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  ELISA (EL/EIA), Western Blot (WB)
• Description
  The Hepatocyte Factor 4 alpha (HNF4 alpha, HNF4alpha, HNF-4-alpha, HNF4a, HNF4, FLJ39654, MODY, MODY1, Receptor Subfamily 2 Group A Member 1, NR2A1, NR2A21, Transcription Factor 14, TCF14, TCF-14, Transcription Factor HNF-4) is a α- or alpha protein sometimes glycoprotein present in blood. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels. The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.

• Gene target
  Hepatocyte   Factor   alpha   HNF4   alpha   HNF4alpha   HNF-4-alpha   HNF4a   HNF4   FLJ39654   MODY   MODY1   Receptor   Subfamily   Group   Member   NR2A1   NR2A21   Transcription   Factor   TCF14   TCF-14   Transcription   Factor   HNF-4  
• Gene symbol
  HNF4A, TCF7L2, ONECUT1, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4
• Short name
  Hepatocyte Factor 4 alpha (HNF4 alpha, HNF4alpha, HNF-4-alpha, HNF4a, HNF4, FLJ39654, MODY, MODY1, Receptor Subfamily 2 Group A Member 1, NR2A1, NR2A21, Transcription Factor 14, TCF14, TCF-14, Transcription Factor HNF-4)
• Host
  Rabbit
• Alternative name
  Hepatocyte Nuclear Factor 4 a (HNF4 a, HNF4alpha, HNF-4-a, HNF4a, HNF4, FLJ39654, MODY, MODY1, Nuclear Receptor Subfamily 2 family A Member 1, NR2A1, NR2A21, Transcription Factor 14, TCF14, TCF-14, Transcription Factor HNF-4)

Gene info

• Identity
  HGNC:5024
• Gene
  HNF4A
• Long gene name
  hepatocyte nuclear factor 4 alpha
• Synonyms gene
  • TCF14
  • MODY
  • MODY1
• Synonyms
  • NR2A1
  • HNF4
• GenBank acession
  • X76930
• Locus
  20q13.12
• Discovery year
  1998-04-20
• Entrez gene record
  3172
• Pubmed identfication
  • 7926813
  • 9048927
• Classification
  • MicroRNA protein coding host genes
  • Hepatocyte nuclear factor 4 family
• VEGA ID
  OTTHUMG00000032531
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_483

Gene info

• Identity
  HGNC:11641
• Gene
  TCF7L2
• Long gene name
  transcription factor 7 like 2
• Synonyms gene
  • TCF4
• Synonyms gene name
  • transcription factor 7-like 2 (T-cell specific, HMG-box)
• Synonyms
  • TCF-4
• GenBank acession
  • X62871
• Locus
  10q25.2-q25.3
• Discovery year
  1998-01-20
• Entrez gene record
  6934
• Pubmed identfication
  • 1741298
• RefSeq identity
  • NM_030756
• Classification
  • TCF/LEF transcription factor family
  • Wnt enhanceosome complex
• VEGA ID
  OTTHUMG00000019070

Gene info

• Identity
  HGNC:8138
• Gene
  ONECUT1
• Long gene name
  one cut homeobox 1
• Synonyms gene
  • HNF6
  • HNF6A
• Synonyms gene name
  • one cut domain, family member 1
• Synonyms
  • HNF-6
• GenBank acession
  • U77975
• Locus
  15q21.3
• Discovery year
  2000-02-11
• Entrez gene record
  3175
• Pubmed identfication
  • 8887657
  • 8790352
• Classification
  • CUT class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000131899

Gene info

• Identity
  HGNC:35296
• Gene
  MIR1302-4
• Long gene name
  microRNA 1302-4
• Synonyms gene
  • MIRN1302-4
• Synonyms
  • hsa-mir-1302-4
• Locus
  2q33.3
• Discovery year
  2008-11-03
• Entrez gene record
  100302130
• RefSeq identity
  • NR_031633
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37522
• Gene
  PIRC18
• Long gene name
  piwi-interacting RNA cluster 18
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313906
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37520
• Gene
  PIRC16
• Long gene name
  piwi-interacting RNA cluster 16
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313849
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32992
• Gene
  SNORD114-4
• Long gene name
  small nucleolar RNA, C/D box 114-4
• Synonyms
  • 14q(II-4)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767580
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003196.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33687
• Gene
  MIR941-4
• Long gene name
  microRNA 941-4
• Synonyms gene
  • MIRN941-4
• Synonyms
  • hsa-mir-941-4
• Locus
  20q13.33
• Discovery year
  2007-10-24
• Entrez gene record
  100126330
• RefSeq identity
  • NR_040032
• Classification
  • MicroRNAs

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