Rabbit Anti Human,Mouse THOC1 Antibody-Non-conjugated
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Catalog numberCSB-PA853419ESR1HU_50ul
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Price:
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Size50ul
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Long nameRabbit Antibody against Human, Mouse THOC1, Non-conjugated
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Synonym nameTHOC1 Human, Mouse Antibody
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Species reactivityHuman,Mouse
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Tested applications recommended dilutionsELISA,WB,IHC,ChIP;Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200
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ConjugationNon-conjugated
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Antibody isotypeIgG
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UniProt IDQ96FV9
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FormatLiquid, diluted in buffer
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Buffer compositionPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Purity>95%
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Purification methodAntigen Affinity Purified Antibodies
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant human THO complex subunit 1 protein (428-657AA)
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Immunogen speciesHuman
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AliasTho1,Nuclear matrix protein p84,p84N5,hTREX84,THOC1,HPR1
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BackgroundRequired for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
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ClonalityPolyclonal antibody
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Shipping and storageTHOC1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus, Oryctolagus cuniculus
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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French translationanticorps
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Gene target
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Gene symbolTHOC1-DT, THOC1
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Short nameAnti-THOC1
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Techniqueanti human, Antibody, Rabbit, Mouse, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates, mouses
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HostRabbit, Rabbits
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SpeciesMouse, Humans, Mouses
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Alternative nameTHOC1 Antibody
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Alternative techniqueantibodies, rabbit-anti, murine
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Alternative to gene targetTHO complex 1, HPR1 and P84 and P84N5, THOC1 and IDBG-282 and ENSG00000079134 and 9984, protein binding, nuclei, Thoc1 and IDBG-128300 and ENSMUSG00000024287 and 225160, THOC1 and IDBG-644087 and ENSBTAG00000019215 and 100138748
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Gene info
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Identity
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Gene
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Long gene nameTHOC1 divergent transcript
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Locus
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Discovery year2020-10-21
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene nameTHO complex 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-12-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- THO complex
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data