EZSolution™ Cyclopamine

• Catalog number
  2545-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  11-deoxojervine
• Description
  Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins.  Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle
• CAS Number
  4449-51-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₄₁NO₂
• Molecular Weight
  411.62
• Cell Permeable
  Yes
• Purity
  ≥99%
• Handling
  Protect from moisture and air
• Tag Line
  A hedgehog signaling inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• MDL Number
  MFCD01735266
• PubChem CID
  442972
• PubChem CID Link
• SMILES
  CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
• InChi
  InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
• InChi Key
  QASFUMOKHFSJGL-LAFRSMQTSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  EZSolution™   Cyclopamine  
• Short name
  EZSolution™ Cyclopamine
• Alternative name
  EZSolution™ Cyclopamine

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