I-CBP112

• Catalog number
  9405-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one
• Description
  I-CBP112 is a selective CBP/EP300 bromodomain inhibitor (IC₅₀ values of 170 nM, 170 nM, 151 nM and 625 nM for CREBBP(Alphascreen), CREBBP(BLI), CREBBP(ITC) and EP300(ITC),respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay.
• CAS Number
  1640282-31-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₆N₂O₅
• Molecular Weight
  468.59
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective CBP/EP300 bromodomain inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  90488984
• PubChem CID Link
• SMILES
  CCC(=O)N1CCOC2=C(C1)C=C(C=C2OCC3CCCN(C3)C)C4=CC(=C(C=C4)OC)OC
• InChi
  InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1
• InChi Key
  YKNAKDFZAWQEEO-IBGZPJMESA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  I-CBP112  
• Gene symbol
  FABP6, TANK, FABP2, PSMB2, CPLX1, MDFI, B3GAT3, IGLVI-38, SNAR-I
• Short name
  I-CBP112
• Alternative name
  I-CBP112

Gene info

• Identity
  HGNC:3561
• Gene
  FABP6
• Long gene name
  fatty acid binding protein 6
• Synonyms gene name
  • fatty acid binding protein 6, ileal
• Synonyms
  • I-15P
  • ILLBP
  • I-BAP
  • ILBP3
  • I-BABP
  • ILBP
  • I-BALB
• Synonyms name
  • illeal lipid-binding protein
  • ileal bile acid binding protein
  • gastrotropin
• GenBank acession
  • U19869
• Locus
  5q33.3
• Discovery year
  1997-09-12
• Entrez gene record
  2172
• Pubmed identfication
  • 7894165
  • 7619861
• RefSeq identity
  • NM_001040442
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130329

Gene info

• Identity
  HGNC:11562
• Gene
  TANK
• Long gene name
  TRAF family member associated NFKB activator
• Synonyms gene
  • TRAF2
• Synonyms gene name
  • TRAF family member-associated NFKB activator
• Synonyms
  • I-TRAF
• GenBank acession
  • U59863
• Locus
  2q24.2
• Discovery year
  1997-06-12
• Entrez gene record
  10010
• Pubmed identfication
  • 8710854
  • 8855313
• RefSeq identity
  • NM_133484
• VEGA ID
  OTTHUMG00000132037

Gene info

• Identity
  HGNC:3556
• Gene
  FABP2
• Long gene name
  fatty acid binding protein 2
• Synonyms gene name
  • fatty acid binding protein 2, intestinal
• Synonyms
  • I-FABP
• GenBank acession
  • J03465
• Locus
  4q26
• Discovery year
  1986-01-01
• Entrez gene record
  2169
• RefSeq identity
  • NM_000134
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000132972

Gene info

• Identity
  HGNC:9539
• Gene
  PSMB2
• Long gene name
  proteasome 20S subunit beta 2
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 2
  • proteasome subunit beta 2
• Synonyms
  • HC7-I
• Synonyms name
  • proteasome subunit β4
• GenBank acession
  • D26599
• Locus
  1p34.3
• Discovery year
  1995-05-03
• Entrez gene record
  5690
• Pubmed identfication
  • 7918633
• RefSeq identity
  • NM_002794
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000004169

Gene info

• Identity
  HGNC:2309
• Gene
  CPLX1
• Long gene name
  complexin 1
• Synonyms
  • CPX-I
• GenBank acession
  • AF022383
• Locus
  4p16.3
• Discovery year
  1999-09-09
• Entrez gene record
  10815
• Pubmed identfication
  • 7553862
• VEGA ID
  OTTHUMG00000160005

Gene info

• Identity
  HGNC:6967
• Gene
  MDFI
• Long gene name
  MyoD family inhibitor
• Synonyms
  • I-mfa
• Synonyms name
  • inhibitor of MyoD family a
• GenBank acession
  • U78313
• Locus
  6p21.1
• Discovery year
  1997-10-17
• Entrez gene record
  4188
• Pubmed identfication
  • 9250874
  • 17289077
• RefSeq identity
  • NM_005586
• VEGA ID
  OTTHUMG00000014681

Gene info

• Identity
  HGNC:923
• Gene
  B3GAT3
• Long gene name
  beta-1,3-glucuronyltransferase 3
• Synonyms gene name
  • beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
• Synonyms
  • GlcAT-I
• Synonyms name
  • glucuronosyltransferase I
  • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
• GenBank acession
  • AB009598
• Locus
  11q12.3
• Discovery year
  2000-01-07
• Entrez gene record
  26229
• Pubmed identfication
  • 9506957
• RefSeq identity
  • NM_012200
• Classification
  • Beta-1,3-glucuronyltransferases
• VEGA ID
  OTTHUMG00000167685

Gene info

• Identity
  HGNC:5935
• Gene
  IGLVI-38
• Long gene name
  immunoglobulin lambda variable (I)-38 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-38
  • immunoglobulin lambda variable (I)-38 pseudogene
• Synonyms
  • IGLV(I)-38
• GenBank acession
  • D87009
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28768
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151073

Gene info

• Identity
  HGNC:34330
• Gene
  SNAR-I
• Long gene name
  small NF90 (ILF3) associated RNA I
• Synonyms gene name
  • small ILF3/NF90-associated RNA I
• Synonyms
  • snaR-3
• Synonyms name
  • small ILF3/NF90-associated RNA 3
• GenBank acession
  • EU071077
• Locus
  3q28
• Discovery year
  2008-07-03
• Entrez gene record
  100170222
• Pubmed identfication
  • 17855395
• RefSeq identity
  • NR_024343
• Classification
  • Small NF90 (ILF3) associated RNAs

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