Lopinavir

Alternative_name

(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Description

A protease inhibitor with high specificity for HIV-1 protease. Inhibition of HIV-1 protease (responsible for protein cleavage), results in selectively inhibiting the cleavage of HIV gag and gag-pol polyproteins, thereby preventing viral maturation.
CAS Number

192725-17-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₇H₄₈N₄O₅
Molecular Weight

628.81
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from light and moisture
Tag Line

A HIV-1 protease inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD04973616
PubChem CID

92727
PubChem CID Link
SMILES

CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O
InChi

InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
InChi Key

KJHKTHWMRKYKJE-SUGCFTRWSA-N
Data Sheet Link
MSDS Available

Yes