PS-1145

Alternative_name

N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Description

PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line.
CAS Number

431898-65-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₇H₁₁ClN₄O
Molecular Weight

322.75
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>5 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective IκB kinase (IKK) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD08705411
PubChem CID

9949093
PubChem CID Link
SMILES

C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4
InChi

InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChi Key

JZRMBDHPALEPDM-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:10690
Gene

CAVIN2
Long gene name

caveolae associated protein 2
Synonyms gene
- SDPR
Synonyms gene name
- serum deprivation response (phosphatidylserine-binding protein)
- serum deprivation response (phosphatidylserine binding protein)
- serum deprivation response
Synonyms
- SDR
- PS-p68
- cavin-2
Synonyms name
- phosphatidylserine binding protein
GenBank acession
- AF085481
Locus

2q32.3
Discovery year

1998-10-30
Entrez gene record

8436
Pubmed identfication
- 10191091
- 8241023
RefSeq identity
- NM_004657
Classification
- Cavins
VEGA ID

OTTHUMG00000154309