TSC1(Ser505) Antibody

• Catalog number
  bs-5600R
• Price
  Please ask
• Size
  0.1ml

• Long name
  TSC1(Ser505) Primary Polyclonal Antibody
• Also known as
  TSC1(Ser505) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TSC1 Ser505
• Specificity
  This is a highly specific antibody against TSC1 Ser505.
• Modification s
  Phosphorylation
• Modification site s
  Ser505
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]
• Gene ID number
  7248
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  TSC1phospho S505; LAM; TSC1; Tuberous sclerosis 1 protein.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TSC1   Ser505  
• Gene symbol
  TSC1
• Short name
  Anti-TSC1 Ser505
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  TSC1(Ser505) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12362
• Gene
  TSC1
• Long gene name
  TSC complex subunit 1
• Synonyms gene
  • TSC
• Synonyms gene name
  • tuberous sclerosis 1
• Synonyms
  • KIAA0243
  • LAM
  • hamartin
• Synonyms name
  • hamartin
• GenBank acession
  • AF013168
• Locus
  9q34
• Discovery year
  1986-01-01
• Pubmed identfication
  • 9242607
  • 10806479
• Classification
  • TSC complex
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000020844
• Locus Specific Databases
  • TSC Mutation Database
  • Global Variome shared LOVD
  • LRG_486

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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