Synaptic Ras-GAP 1 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-11369R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  Synaptic Ras-GAP 1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-SynGAP PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  SynGAP
• Specificity
  This is a highly specific antibody against SynGAP.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Synaptic Ras-GAP 1/SynGAP
• Gene ID Number
  8831
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  Neuronal RasGAP; p135 SynGAP; Ras GTPase activating protein SynGAP; Ras GTPase-activating protein SynGAP; RASA 1; RASA 5; RASA1; RASA5; SYGP1_HUMAN; Synaptic Ras GAP 1; Synaptic Ras GTPase activating protein 1; Synaptic Ras GTPase activating protein 1 homolog; Synaptic Ras GTPase activating protein 135kDa; synaptic Ras GTPase activating protein; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP 1; SYNGAP1; DKFZp761G1421; KIAA1938; MRD5; OTTHUMP00000064825; SYNGAP1.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-SynGAP has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  Synaptic   Ras-GAP  
• Gene symbol
  GAP43, ARHGAP32, ITGA3, RASA1
• Short name
  Anti-SynGAP
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  Synaptic Ras-GAP 1 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4140
• Gene
  GAP43
• Long gene name
  growth associated protein 43
• Synonyms
  • B-50
  • PP46
  • GAP-43
• Synonyms name
  • neuron growth-associated protein 43
  • neuromodulin
  • nerve growth-related peptide GAP43
  • axonal membrane protein GAP-43
  • protein F1
  • calmodulin-binding protein P-57
  • neural phosphoprotein B-50
• Locus
  3q13.31
• Discovery year
  1990-07-10
• Entrez gene record
  2596
• Pubmed identfication
  • 3272162
  • 8231732
• RefSeq identity
  • NM_002045
• VEGA ID
  OTTHUMG00000133758

Gene info

• Identity
  HGNC:17399
• Gene
  ARHGAP32
• Long gene name
  Rho GTPase activating protein 32
• Synonyms
  • GRIT
  • KIAA0712
  • MGC1892
  • RICS
  • GC-GAP
• GenBank acession
  • AB018255
• Locus
  11q24.3
• Discovery year
  2010-02-19
• Entrez gene record
  9743
• Pubmed identfication
  • 12446789
  • 12819203
  • 17663722
• RefSeq identity
  • NM_014715
• Classification
  • Rho GTPase activating proteins
• VEGA ID
  OTTHUMG00000165774

Gene info

• Identity
  HGNC:6139
• Gene
  ITGA3
• Long gene name
  integrin subunit alpha 3
• Synonyms gene
  • MSK18
• Synonyms gene name
  • antigen identified by monoclonal antibody J143
  • integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
• Synonyms
  • CD49c
  • VLA3a
  • VCA-2
  • GAP-B3
• Synonyms name
  • alpha 3 subunit of VLA-3 receptor
  • antigen CD49C
• GenBank acession
  • M59911
• Locus
  17q21.33
• Discovery year
  1992-02-27
• Entrez gene record
  3675
• Pubmed identfication
  • 1655803
  • 9704023
• RefSeq identity
  • NM_005501
• Classification
  • Integrin alpha subunits
  • CD molecules
• VEGA ID
  OTTHUMG00000161890

Gene info

• Identity
  HGNC:9871
• Gene
  RASA1
• Long gene name
  RAS p21 protein activator 1
• Synonyms gene
  • RASA
• Synonyms gene name
  • RAS p21 protein activator (GTPase activating protein) 1
• Synonyms
  • GAP
  • CM-AVM
  • p120GAP
  • p120RASGAP
  • p120
• Synonyms name
  • capillary malformation-arteriovenous malformation
  • p120 RAS GTPase activating protein
• Locus
  5q14.3
• Discovery year
  1989-06-30
• Entrez gene record
  5921
• Pubmed identfication
  • 15917201
• RefSeq identity
  • NM_002890
• Classification
  • SH2 domain containing
  • C2 and RasGAP domain containing
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000162605
• Locus Specific Databases
  • SH2base: Database for pathogenic SH2 domain mutations

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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