IPI-549

Alternative_name

2-amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Description

IPI-549 is a potent and selective PI3Kγ Inhibitor (IC₅₀ of 16 nM). It displays no significant inhibition for a panel of 468 mutant and non-mutant protein and lipid kinases (including Class II PI3K isoforms) at 1 µM.
CAS Number

1693758-51-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₀H₂₄N₈O₂
Molecular Weight

528.56
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~15 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective PI3Kγ Inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

118004470
PubChem CID Link
SMILES

CC(C1=CC2=CC=CC(=C2C(=O)N1C3=CC=CC=C3)C#CC4=CN(N=C4)C)NC(=O)C5=C6N=CC=CN6N=C5N
InChi

InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)
InChi Key

XUMALORDVCFWKV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes