SIAH1/2 Antibody, ALEXA FLUOR 594
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Catalog number
bs-3634R-A594
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Price
Please ask
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Size
100ul
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Long name
SIAH1/2 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known as
Anti-SIAH1/2 PAb ALEXA FLUOR 594
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 594
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
SIAH1/2
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Specificity
This is a highly specific antibody against SIAH1/2.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen range
200-250/324
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Subcellular location
Cytoplasm, Nucleus
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIAH2
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Gene ID Number
6478, 6477
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Swiss Prot
O43255, Q8IUQ4
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
590nm/617nm
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Synonyms
Seven in Absentia Homolog 2; Ubiquitin Ligase Siah2; SIAH2_HUMAN; E3 ubiquitin-protein ligase SIAH2; Seven in absentia homolog 2; Siah-2; hSiah2; Siah-1; Siah-1a; E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1.
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Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR® 594
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Conjugated
Alexa conjugate 1
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French translation
anticorps
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Gene target
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Gene symbol
SIAH1
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Short name
Anti-SIAH1/2
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 594
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Alternative name
SIAH1/2 Polyclonal Antibody, ALEXA FLUOR 594
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Alternative technique
antibodies
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Alternative to gene target
siah E3 ubiquitin protein ligase 1, SIAH1A, SIAH1 and IDBG-30112 and ENSG00000196470 and 6477, ligase activity, nuclei, BT.37798 and IDBG-631496 and ENSBTAG00000010868 and 534655
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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