RAT ANTI MOUSE CD276 Antibody

• Catalog number
  GEN224597
• Price
  Please ask
• Size
  0.25 miligrams

• Also known as
  CD276
• Other names
  CD276 antigen; CD276 antigen; CD276 antigen; B7-H3; B7 homolog 3; costimulatory molecule; CD276 antigen; B7 homolog 3; B7-H3; Costimulatory molecule
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  CD276
• Gene name synonims
  N/A
• Other gene names
  Cd276; Cd276; B7h3; B7RP-2; AU016588; 6030411F23Rik; B7h3; B7-H3
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1
• Clone
  MJ18
• Host organism
  Rat (Rattus norvegicus)
• Species reactivity
  Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  CD276 This item specifically recognises mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma Studies have shown that clone MJ18 inhibits stimulated CD4+ T-cell proliferation; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  Purified (Purified IgG - liquid)
• Concentration
  IgG concentration 1.0mg/ml
• Storage and shipping
  Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.
• Tested applications
  Flow Cytometry (FACS)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus, Rattus norvegicus
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• French translation
  anticorps

• Gene target
  CD276  
• Gene symbol
  CD276
• Short name
  ANTI MOUSE CD276 Antibody
• Technique
  anti mouse, Antibody, Mouse, anti, antibody to, anti mouse antibodies, antibodies against human proteins, antibodies for, mouses
• Host
  Rat
• Species
  Mouse, Mouses, Rats
• Alternative name
  Anti-RAT ANTI MOUSE CD276
• Alternative technique
  antibodies, murine
• Alternative to gene target
  CD276 molecule, CD276 and IDBG-21197 and ENSG00000103855 and 80381, protein binding, Cell surfaces, Cd276 and IDBG-172080 and ENSMUSG00000035914 and 102657, CD276 and IDBG-645646 and ENSBTAG00000019734 and 508656

Gene info

• Identity
  HGNC:19137
• Gene
  CD276
• Long gene name
  CD276 molecule
• Synonyms gene name
  • CD276 antigen
• Synonyms
  • B7-H3
  • B7H3
  • B7RP-2
• GenBank acession
  • AF302102
• Locus
  15q24.1
• Discovery year
  2005-03-04
• Entrez gene record
  80381
• Pubmed identfication
  • 11224528
  • 12055244
• RefSeq identity
  • NM_025240
• Classification
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000137585

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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