Mouse anti Fibronectin

• Catalog number
  MUB0602S
• Price
  Please ask
• Size
  1 mL

• Category
  Primary Antibodies
• Long description
  Fibronectin is a disulfide-bonded dimer of 230-250 kD. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodelling. Fibronectin is also present at high concentRations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).
• Antibody come from
  EP-5 is a Mouse monoclonal IgG1 antibody.
• Other description
  Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.
• Clone
  EP-5
• Antigen antibody binding interaction
  Mouse anti Fibronectin Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human,Mouse
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  EP-5 reacts with fibronectin in connective tissues and vessels. Animal biodistribution experiments have shown that after intravenous administRation, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indiCating that this antibody can be used to target tumor vessels specifically in vivo.
• Research interest
  Cell adhesion
• Application
  Immunohistochemistry (frozen)
• Antibody s suited for
  EP-5 is useful for immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration; recommended range is 1:2 – 1:10 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent.
• Storage
  Store at 4°C, or in small aliquots at -20°C.
• Relevant references
  1. No references available
• Protein number
  P02751
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Fibronectin  
• Gene symbol
  FANK1, FNDC3A, FLRT3
• Short name
  Mouse anti Fibronectin
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG1
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to Fibronectin
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:23527
• Gene
  FANK1
• Long gene name
  fibronectin type III and ankyrin repeat domains 1
• Synonyms gene name
  • fibronectin type 3 and ankyrin repeat domains 1
• GenBank acession
  • BC024189
• Locus
  10q26.2
• Discovery year
  2003-11-21
• Entrez gene record
  92565
• Pubmed identfication
  • 17604233
• RefSeq identity
  • NM_145235
• Classification
  • Ankyrin repeat domain containing
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000019241

Gene info

• Identity
  HGNC:20296
• Gene
  FNDC3A
• Long gene name
  fibronectin type III domain containing 3A
• Synonyms gene
  • FNDC3
• Synonyms gene name
  • fibronectin type III domain containing 3
• Synonyms
  • bA203I16.5
  • KIAA0970
• GenBank acession
  • AB023187
• Locus
  13q14.2
• Discovery year
  2004-04-16
• Entrez gene record
  22862
• RefSeq identity
  • NM_014923
• Classification
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000016911

Gene info

• Identity
  HGNC:3762
• Gene
  FLRT3
• Long gene name
  fibronectin leucine rich transmembrane protein 3
• GenBank acession
  • AF169677
• Locus
  20p12.1
• Discovery year
  1999-10-29
• Entrez gene record
  23767
• Pubmed identfication
  • 10644439
• RefSeq identity
  • NM_013281
• Classification
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000031914

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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