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FLI 06 for cell activation

FLI 06 for cell activation is available 2 times from Biovision labs

2603-5 | FLI-06 for cell activation size: 5 mg | 211.50 USD

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2603-25 | FLI-06 for cell activation size: 25 mg | 656.11 USD

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Other name Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Supplied with N/A
Description A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.
Category Biochemicals
Molecular formula C₂₅H₃₀N₂O₅
Is it cell-permeable? Yes
Molecular weight 438.52
Storage condition -20 ̊C
Shipping condition Gel pack
Purification >98% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 313967-18-9
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance Yellow solid
Reconstitute instructions DMSO (~40 mg/ml) or EtOH (~ 8 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetFLI-06 for activation
Short name FLI-06 for activation
Technique activation
Alternative name FLI-06 to measure cellular activation
Tissue cell
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