RBC8

• Catalog number
  B1136-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
• Description
  RBC8 is cell-permeable small molecule that inhibits the binding of Ras-like GTPases A and B ( RalA and RalB GTPase ) to RaLBP1 and shown to suppress growth of xenograft tumors in mice. It reduces the activation of RaiA in living cells Ral is needed for the growth of murine embryonic fibroblasts (MEFs). Ral pull down assay showes that RBC8 inhibits the activation of both RalA and RalB in the H2122 and H358 cell lines.
• CAS Number
  361185-42-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₂₀N₄O₃
• Molecular Weight
  424.45
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (> 40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  RalA and RalB GTPase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  6626226
• PubChem CID Link
• SMILES
  COC1=CC(=C(C=C1)OC)C2C(=C(OC3=NNC(=C23)C4=CC5=CC=CC=C5C=C4)N)C#N
• InChi
  1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)
• InChi Key
  CLMQBVUFKIKYLU-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  RBC8  
• Short name
  RBC8
• Alternative name
  RBC8

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