Z-AEVD-FMK
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Catalog numberB1162-1
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PricePlease ask
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Size1 mg
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Alternative_nameZ-A-E(OMe)-V-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; FK033
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DescriptionZ-AEVD-FMK is a synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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CAS Number1135688-47-9
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Structure AvailableYes
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Peptide sequenceZ-Ala-Glu(OMe)-Val-Asp(OMe)-FMK
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Salt FormNo
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Molecular FormulaC₂₈H₃₉FN₄O₁₀
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Molecular Weight610.63
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesDMSO (~ 10 mg/ml)
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HandlingProtect from air and light
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Tag LineA caspase-10 inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD03453601
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PubChem CID25108694
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SMILESCC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1
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InChiInChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1
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InChi KeyCHZRBQFKZDGMTP-CDSYHYPYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolPSMB7, PLA2G4F, HLA-Z, ZNF276
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Short nameZ-AEVD-FMK
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Alternative nameZ-AEVD-FMK
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Gene info
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Identity
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Gene
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Long gene nameproteasome 20S subunit beta 7
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Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-11-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proteasome
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephospholipase A2 group IVF
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Synonyms gene name
- phospholipase A2, group IVF
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Synonyms
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Locus
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Discovery year2005-11-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C2 domain containing phospholipases
- Phospholipases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, Z (pseudogene)
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Synonyms
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Locus
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Discovery year2002-10-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namezinc finger protein 276
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Synonyms gene
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Synonyms gene name
- zinc finger protein 276 homolog (mouse)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers C2H2-type
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VEGA ID