CASP3, Caspase-3

• Catalog number
  AS16 4001
• Price
  Please ask
• Size
  100 µg

• Available ordering format
  Liquid
• Immunogen
  Recombinant human Caspase-3 protein. UniProt: P42574
• Raised in
  Mouse
• Clonality
  Monoclonal
• Clone
  AM1 4 , IgG
• Purification
  Protein A/G purified.
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  Store at -20°C.
• Verified applications
  Western Blot (WB)
• Connected products
  anti-mouse secondary antibodies
• Recommended dilutions for use
  Optimal concentrations should be determined by serial dilutions.
• Molecular weight expected аpparent
  see datasheet
• Verified reactivity
  Human
• Possible reactivity
  to be determined
• No reactivity
  No confirmed exceptions from predicted reactivity known at the moment.
• Supplementary information
  Contact Gentaur support center at [email protected]
• References
  To be added when available, antibody released in November 2016.
• Scientific context
  Caspase-3 is involved in the activation cascade of caspases, this cascade is responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 belongs to the group of effector caspases that are involved in the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others._x000B_
• Notes
  Provided in phosphate buffered saline, contains 0.08% sodium azide.
• Protein number
  P42574
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

• Gene target
  CASP3   Caspase-3  
• Gene symbol
  CASP3
• Short name
  CASP3, Caspase-3
• Alternative name
  caspase 3, apoptosis-related cysteine peptidase, caspase-3
• Alternative to gene target
  caspase 3, apoptosis-related cysteine peptidase, CPP32 and CPP32B and SCA-1, CASP3 and IDBG-46394 and ENSG00000164305 and 836, cysteine-type endopeptidase activity involved in execution phase of apoptosis, nuclei, Casp3 and IDBG-154306 and ENSMUSG00000031628 and 12367, CASP3 and IDBG-628521 and ENSBTAG00000015874 and 408016

Gene info

• Identity
  HGNC:1504
• Gene
  CASP3
• Long gene name
  caspase 3
• Synonyms gene name
  • caspase 3, apoptosis-related cysteine protease
  • caspase 3, apoptosis-related cysteine peptidase
• Synonyms
  • CPP32
  • CPP32B
  • Yama
  • apopain
• GenBank acession
  • BC016926
• Locus
  4q35.1
• Discovery year
  1996-07-22
• Entrez gene record
  836
• Pubmed identfication
  • 8780721
• RefSeq identity
  • NM_004346
• Classification
  • Caspases
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000133681

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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