Vandetanib

• Catalog number
  1751-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima
• Description
  A potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC₅₀ = 40 nM).  This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC₅₀ = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC₅₀ = 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.
• CAS Number
  443913-73-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₂₄BrFN₄O₂
• Molecular Weight
  475.35
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (30 mg/ml) or EtOH (10 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent VEGFR kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD07772346
• PubChem CID
  3081361
• PubChem CID Link
• SMILES
  CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
• InChi
  InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
• InChi Key
  UHTHHESEBZOYNR-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Vandetanib  
• Short name
  Vandetanib
• Alternative name
  Vandetanib

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