TGR-1202

• Catalog number
  B1284-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one; RP5264
• Description
  TGR-1202 (also known as RP5264), is a highly specific inhibitor of PI3Kδ, targeting the δ isoform with nanomolar potency and several-fold selectivity over the α, β, and g isoforms of PI3K.
• CAS Number
  1532533-67-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₁H₂₄F₃NO₃
• Molecular Weight
  571.56
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A highly specific PI3Kδ inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  72950888
• PubChem CID Link
• SMILES
  C(C)OC1=C(C=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)C4=C(C(=O)C5=C(O4)C=CC(=C5)F)C6=CC(=CC=C6)F)F
• InChi
  InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1
• InChi Key
  IUVCFHHAEHNCFT-INIZCTEOSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TGR-1202  
• Gene symbol
  MIR1202, TXNRD3
• Short name
  TGR-1202
• Alternative name
  TGR-1202

Gene info

• Identity
  HGNC:35268
• Gene
  MIR1202
• Long gene name
  microRNA 1202
• Synonyms gene
  • MIRN1202
• Synonyms
  • hsa-mir-1202
• Locus
  6q25.3
• Discovery year
  2008-11-03
• Entrez gene record
  100302259
• RefSeq identity
  • NR_031606
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:20667
• Gene
  TXNRD3
• Long gene name
  thioredoxin reductase 3
• Synonyms gene
  • TXNRD3NB
  • TXNRD3IT1
• Synonyms gene name
  • thioredoxin reductase 3 neighbor
  • thioredoxin reductase 3 intronic transcript 1
• Synonyms
  • TR2
  • TRXR3
  • TGR
  • TR2IT1
  • TXNRD3NT1
• Synonyms name
  • thioredoxin glutathione reductase
  • selenoprotein TXNRD3
• GenBank acession
  • AF133519
• Locus
  3q21.3
• Discovery year
  2003-09-11
• Entrez gene record
  114112
• Pubmed identfication
  • 10455115
  • 12530083
• RefSeq identity
  • NM_052883
• Classification
  • Glutaredoxin domain containing
  • Selenoproteins
• VEGA ID
  OTTHUMG00000162733

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