MMAE

• Catalog number
  B2344-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide,Monomethyl auristatin E
• Description
  MMAE (Monomethyl auristatin E) is a synthetic derivative of dolastatin 10 that functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.
• CAS Number
  474645-27-7
• Structure Available
  Yes
• Molecular Formula
  C₃₉H₆₇N₅O₇
• Molecular Weight
  717.98
• Cell Permeable
  1
• Purity
  ≥98% by HPLC
• Solubilities
  >50 mg/ml (DMSO)
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A tubulin polymerization inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD22124498
• PubChem CID
  11542188
• PubChem CID Link
• SMILES
  CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC
• InChi
  InChI=1S/C39H67N5O7/c1-13-25(6)34(43(10)39(49)33(24(4)5)42-38(48)32(40-9)23(2)3)30(50-11)22-31(45)44-21-17-20-29(44)36(51-12)26(7)37(47)41-27(8)35(46)28-18-15-14-16-19-28/h14-16,18-19,23-27,29-30,32-36,40,46H,13,17,20-22H2,1-12H3,(H,41,47)(H,42,48)/t25-,26+,27+,29-,30+,32-,33-,34-,35+,36+/m0/s1
• InChi Key
  DASWEROEPLKSEI-UIJRFTGLSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  MMAE  
• Short name
  MMAE
• Alternative name
  MMAE

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