Z-YVAD-FMK

Alternative_name

Z-YVAD-FMK, Z-YVAD-fluoromethylketone, Caspase-1 Inhibitor (fluoromethylketone)
Description

A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Structure Available

No
Peptide sequence

Z-Tyr-Val-Ala-Asp(OMe)-FMK
Salt Form

No
Molecular Formula

C₃₁H₃₉FN₄O₉
Molecular Weight

630.7
Cell Permeable

Yes
Purity

Single spot by TLC
Solubilities

DMSO (20 mM)
Handling

Protect from light and moisture
Tag Line

A caspase-1 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

12 months
PubChem CID

16760349
PubChem CID Link
SMILES

CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2
InChi

InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32) 15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21- 8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34, 40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1
InChi Key

MVPQJUFFTWWKBT-UYDLRUHXSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042