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Alternative_name
6-amino-3-pyridinecarboxamide; 6-AN; NSC21206; SR4388
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Description
6-aminonicotinamide (6-AN) is inhibitor of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the conversion of G-6-P to 6-phosphogluconolactone, the first step of the pentose phosphate pathway. 6-AN has been widely used as a chemical tool in various experimental systems to study the biological consequences of inhibiting pentose phosphate pathway. Due to the essential roles of this pathway in generating reducing power (NADPH) and important metabolic intermediates (pentose-5-phosphate) for synthesis of macromolecules, it is not surprising that 6-AN exhibits anticancer activity in vitro, causes oxidative stress, and sensitizes cells to anticancer agents and radiation.
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CAS Number
329-89-5
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₆H₇N₃O
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Molecular Weight
137.1
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~ 1 mg/ml)
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Handling
Protect from air and light
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Tag Line
An inhibitor of glucose-6-phosphate dehydrogenase (G6PD)
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00006327
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PubChem CID
9500
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SMILES
C1=CC(=NC=C1C(=O)N)N
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InChi
InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)
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InChi Key
ZLWYEPMDOUQDBW-UHFFFAOYSA-N
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MSDS Available
Yes
