SR1001

Alternative_name

N-(5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
Description

Cell-permeable. A high affinity synthetic ligand specific to both retinoic acid-related orphan receptors ɑ (RORɑ) and γt (RORγt). SR1001 inhibits interleukin-17 (TH17) cell differentiation and function as well as suppressing the clinical severity of autoimmune disease in mice.
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₅H₁₃F₆N₃O₄S₂
Molecular Weight

477.4
Cell Permeable

Yes
Purity

≥98% by TLC and NMR
Solubilities

DMSO (10 mg/ml)
Handling

Protect from air and moisture
Tag Line

A high affinity synthetic ligand to retinoic acid-related orphan receptors ɑ (RORɑ) and γt
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
SMILES

N/A
InChi

N/A
InChi Key

N/A
Data Sheet Link
MSDS Available

Yes