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Form
liquid
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Purification
Immunogen affinity purified
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Purity
≥95% as determined by SDS-PAGE
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Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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Immunogen
proteasome (prosome, macropain) 26S subunit, ATPase, 2
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Synonyms
MSS1
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Calculated MW
125 kDa
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Uniprot ID
P35998
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Specificity
Human, Mouse
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Tested Application
ELISA, WB, IHC, IF
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Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
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Image1
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab06878(PSMC2 antibody) at dilution of 1:100
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Image4
human adrenal gland tissue were subjected to SDS PAGE followed by western blot with FNab06878(PSMC2 antibody) at dilution of 1:1000
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Properties
If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
PSMC2
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Short name
anti- PSMC2 antibody
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Technique
Antibody, anti, antibody to, antibodies against human proteins, antibodies for
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Host
Rabbit
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Isotype
IgG
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Alternative name
antibody to- proteasome (prosome, macropain) 26S subunit, ATPase, 2 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
proteasome (prosome, macropain) 26S subunit, ATPase, 2, MSS1 and Nbla10058 and S7, PSMC2 and IDBG-34377 and ENSG00000161057 and 5701, nucleoside-triphosphatase activity, nuclei, Psmc2 and IDBG-138522 and ENSMUSG00000028932 and 19181, PSMC2 and IDBG-631490 and ENSBTAG00000046712 and 530186
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