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Synonyms
TNFRSF17, CD269, BCM, BCMA
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Alternative_names
TNFRSF17, CD269, BCM, BCMA
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Description
A member of the TNF receptor superfamily
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Recombinant
Yes
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Source
HEK 293 cells
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Purity by SDS PAGE
≥90%
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Assay
SDS-PAGE
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Endotoxin Level
< 1 EU/ug
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Activity Specifications test method
Measured by its binding ability in a functional ELISA.
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Biological activity
Immobilized Human BCMA, His Tag at 5 ug/mL (100 uL/well) can bind Biotinylated Human BAFF with a linear range of 0.24-3.9 ng/mL.
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Binding Capacity
Immobilized Human BCMA, His Tag at 5 ug/mL (100 uL/well) can bind Biotinylated Human BAFF with a linear range of 0.24-3.9 ng/mL.
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Molecular Weight
7.5 kDa
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Storage Temp
-20°C
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Shipping
Gel pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
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Reconstitution Instructions
Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
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Background Information
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
TNFRSF17
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Short name
CellExp™ BCMA / TNFRSF17, recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Humans
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Alternative name
H. sapiens CellExp™ BCMA / tumor necrosis factor receptor superfamily, member 17, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
tumor necrosis factor receptor superfamily, member 17, BCM and BCMA and CD269 and TNFRSF13A, TNFRSF17 and IDBG-15042 and ENSG00000048462 and 608, tumor necrosis factor-activated receptor activity, Plasma membranes, Tnfrsf17 and IDBG-133357 and ENSMUSG00000022496 and 21935
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