PF-573228

Alternative_name

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
Description

PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC₅₀ = 4 nM). PF-573,228 inhibits FAK phosphorylation on Tyr(397) with an IC₅₀ of 30-100 nM. Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover in vitro.
CAS Number

869288-64-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₀F₃N₅O₃S
Molecular Weight

491.49
Cell Permeable

yes
Purity

≥98% by HPLC
Solubilities

DMSO (>40 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective focal adhesion kinase (FAK) inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD11519967
PubChem CID

11612883
PubChem CID Link
SMILES

CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
InChi

InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)
InChi Key

HESLKTSGTIBHJU-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes