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Caspase 8 human recombinant

Caspase 8 human recombinant is available 2 times from Biovision labs

1088-100 | Caspase-8, human recombinant size: 100units | 606.05 USD

Catalog number 1088-100
Supplier Biovision
Price 606.05 USD
Size 100units
Alternates names Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Taglines A cysteine-aspartic acid protease involved in apoptosis
Biomolecule/Target Caspase-8
NCBI Gene ID #. 841
NCBI Gene Symbol CASP8
Gene Source Human
Accession # Q14790
Purity N/A
Endotoxin Level N/A
Biological activity N/A
Results N/A
Molecular Weight N/A
Concentration N/A
1. Gene info
Identity 1509
Gene CASP8
Long gene name caspase 8
Synonyms gene name
  • caspase 8, apoptosis-related cysteine protease
  • caspase 8, apoptosis-related cysteine peptidase
Synonyms
  • MCH5
  • MACH
  • FLICE
  • Casp-8
GenBank acession
  • U60520
Locus 2q33.1
Discovery year 1996-11-11
Entrez gene record 841
Pubmed identfication
  • 8681376
  • 8681377
RefSeq identity
  • NM_001228
Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
Havana BLAST/BLAT OTTHUMG00000132821
Locus Specific Databases
  • CASP8base: Mutation registry for Caspase 8 deficiency
  • LRG_34
Product images
    #Human#.jpg#0#.jpeg

1088-25 | Caspase-8, human recombinant size: 25 units | 430.30 USD

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Synonyms Caspase-8
Alternative_names Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Description A cysteine-aspartic acid protease involved in apoptosis
Recombinant Yes
Source E. coli.
Assay SDS-PAGE
Activity (Specifications/test method) > 5000 units/mg
Unit Definition One unit of the recombinant caspase-8 is the enzyme activity that cleaves 1 nmol of the caspase substrate IETD-pNA (pNA: pnitroanaline) per hour at 37°C in a reaction solution containing 50 mM Hepes, pH 7.2, 50 mM NaCl, 0.1% Chaps, 10 mM EDTA, 5% Glycerol, and 10 mM DTT.
Storage Temp. -70°C
Shipping gel pack
Shelf Life 12 months
Appearance Lyophilized powder
Physical form description Lyophilized powder
Reconstitution Instructions Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Background Information Caspase-8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Active caspase-8 has been shown to activate caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis. The recombinant active human caspase-8 was expressed in E. coli. The active caspase-8 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA (Cat. #1063-200) or Ac-IETD-AFC (1062-200).
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Additional description Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Gene targetCaspase-8
Short name Caspase-8, recombinant
Technique Recombinant
Species Human
Alternative name caspase-8, H. sapiens recombinant
Alternative technique rec
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