SMER28

• Catalog number
  1856-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
• Description
  Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).
• CAS Number
  307538-42-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₁H₁₀BrN₃
• Molecular Weight
  264.12
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A positive regulator of autophagy
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD02166825
• PubChem CID
  1560402
• PubChem CID Link
• SMILES
  C=CCNC1=NC=NC2=C1C=C(C=C2)Br
• InChi
  InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
• InChi Key
  BCPOLXUSCUFDGE-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SMER28  
• Short name
  SMER28
• Alternative name
  SMER28

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