FAN1 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-13137R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  FAN1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-FAN1 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  FAN1
• Specificity
  This is a highly specific antibody against FAN1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  400-450/1017
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FAN1
• Gene ID Number
  22909
• Swiss Prot
  Q9Y2M0
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  KMIN; hFAN1; MTMR15; KIAA1018; Fanconi-associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Myotubularin-related protein 15; FAN1
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-FAN1 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  FAN1  
• Gene symbol
  FAN1
• Short name
  Anti-FAN1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  FAN1 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies
• Alternative to gene target
  FANCD2/FANCI-associated nuclease 1, KIAA1018 and KMIN and MTMR15, FAN1 and IDBG-4900 and ENSG00000198690 and 22909, hydrolase activity, nuclei, Fan1 and IDBG-191028 and ENSMUSG00000033458 and 330554, FAN1 and IDBG-630438 and ENSBTAG00000009855 and 508171

Gene info

• Identity
  HGNC:29170
• Gene
  FAN1
• Long gene name
  FANCD2 and FANCI associated nuclease 1
• Synonyms gene
  • KIAA1018
  • MTMR15
• Synonyms gene name
  • KIAA1018
  • myotubularin related protein 15
  • FANCD2/FANCI-associated nuclease 1
• Locus
  15q13.3
• Discovery year
  2005-10-28
• Entrez gene record
  22909
• Pubmed identfication
  • 20603015
  • 20603016
  • 20603073
• RefSeq identity
  • NM_014967
• VEGA ID
  OTTHUMG00000175661

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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