ITF2357

• Catalog number
  9431-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride, monohydrate; Givinostat
• Description
  ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties.  ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the secretion of IL-1β and other cytokines at 25-100 nM.
• CAS Number
  732302-99-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₇N₃O₄.HCl.H₂O
• Molecular Weight
  475.97
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A pan-HDAC inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9804991
• PubChem CID Link
• SMILES
  CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl
• InChi
  InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2
• InChi Key
  FKGKZBBDJSKCIS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ITF2357  
• Short name
  ITF2357
• Alternative name
  ITF2357

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