HM-30181

Alternative_name

4-Oxo-4H-chromene-2-carboxylic acid [2-(2-4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl-2H-tetrazol-5-yl)-4,5-dimethoxy-phenyl]-amide
Description

HM-30181 is a third-generation P-glycoprotein (P-gp) inhibitor. In an in vitro, HM-30181 displays a high selectivity for P-gp and its potency is 20–50 times higher than that of tariquidar (Cat. No. 2853), another third-generation P-gp inhibitor.
CAS Number

849675-66-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₈H₃₆N₆O₇
Molecular Weight

688.73
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A third-generation P-glycoprotein (P-gp) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

11399764
PubChem CID Link
SMILES

COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)N4N=C(N=N4)C5=CC(=C(C=C5NC(=O)C6=CC(=O)C7=CC=CC=C7O6)OC)OC)OC
InChi

InChI=1S/C38H36N6O7/c1-47-32-17-24-14-16-43(22-25(24)18-33(32)48-2)15-13-23-9-11-26(12-10-23)44-41-37(40-42-44)28-19-34(49-3)35(50-4)20-29(28)39-38(46)36-21-30(45)27-7-5-6-8-31(27)51-36/h5-12,17-21H,13-16,22H2,1-4H3,(H,39,46)
InChi Key

AHJUHHDDCJQACA-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes