TAK-733

Alternative_name

(R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
Description

A potent, selective, non-ATP competitive, allosteric MEK inhibitor. TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
CAS Number

1035555-63-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₇H₁₅F₂IN₄O₄
Molecular Weight

504.23
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>100 mg/ml)
Handling

Protect from air and light
Tag Line

A selective MEK1/2 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
PubChem CID

24963252
PubChem CID Link
SMILES

CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O
InChi

InChI=1S/C17H15F2IN4O4/c1-23-15-12(16(27)24(7-21-15)5-9(26)6-25)14(13(19)17(23)28)22-11-3-2-8(20)4-10(11)18/h2-4,7,9,22,25-26H,5-6H2,1H3/t9-/m1/s1
InChi Key

RCLQNICOARASSR-SECBINFHSA-N
Data Sheet Link
MSDS Available

Yes