SAR-20347

• Catalog number
  B1290-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-(2-Chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide
• Description
  SAR-20347 is a novel specific dual inhibitor of JAK1 and tyrosine kinase 2 (TYK2), inhibiting JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors.
• CAS Number
  1450881-55-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₈ClFN₄O₄
• Molecular Weight
  444.84
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A novel specific dual inhibitor of JAK1 and tyrosine kinase 2 (TYK2)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  71727668
• PubChem CID Link
• SMILES
  C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N
• InChi
  InChI=1S/C21H18ClFN4O4/c22-14-2-1-3-15(23)16(14)19-26-17(18(24)28)20(31-19)25-13-6-4-12(5-7-13)21(29)27-8-10-30-11-9-27/h1-7,25H,8-11H2,(H2,24,28)
• InChi Key
  HEDPDFHTQKEORT-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SAR-20347  
• Gene symbol
  SRL, CCDC73, CCDC18, HAUS8, FMR1NB, MEAF6
• Short name
  SAR-20347
• Alternative name
  SAR-20347

Gene info

• Identity
  HGNC:11295
• Gene
  SRL
• Long gene name
  sarcalumenin
• Synonyms
  • SAR
• GenBank acession
  • AK056588
• Locus
  16p13.3
• Discovery year
  1992-07-20
• Entrez gene record
  6345
• Pubmed identfication
  • 2762314
• RefSeq identity
  • NM_001098814
• VEGA ID
  OTTHUMG00000177617

Gene info

• Identity
  HGNC:23261
• Gene
  CCDC73
• Long gene name
  coiled-coil domain containing 73
• Synonyms
  • NY-SAR-79
• GenBank acession
  • AK128159
• Locus
  11p13
• Discovery year
  2006-02-11
• Entrez gene record
  493860
• RefSeq identity
  • NM_001008391
• VEGA ID
  OTTHUMG00000166279

Gene info

• Identity
  HGNC:30370
• Gene
  CCDC18
• Long gene name
  coiled-coil domain containing 18
• Synonyms
  • NY-SAR-41
• Locus
  1p22.1
• Discovery year
  2005-06-24
• Entrez gene record
  343099
• Pubmed identfication
  • 12601173
• RefSeq identity
  • NM_206886
• VEGA ID
  OTTHUMG00000010598

Gene info

• Identity
  HGNC:30532
• Gene
  HAUS8
• Long gene name
  HAUS augmin like complex subunit 8
• Synonyms gene
  • HICE1
• Synonyms gene name
  • HEC1/NDC80 interacting, centrosome associated 1
• Synonyms
  • MGC20533
  • NY-SAR-48
• GenBank acession
  • BC004398
• Locus
  19p13.11
• Discovery year
  2008-12-16
• Entrez gene record
  93323
• Pubmed identfication
  • 19427217
• RefSeq identity
  • NM_001011699
• Classification
  • HAUS augmin like complex
• VEGA ID
  OTTHUMG00000182672

Gene info

• Identity
  HGNC:26372
• Gene
  FMR1NB
• Long gene name
  FMR1 neighbor
• Synonyms gene name
  • fragile X mental retardation 1 neighbor
• Synonyms
  • FLJ25736
  • NY-SAR-35
  • CT37
• Synonyms name
  • cancer/testis antigen 37
• Locus
  Xq27.3-q28
• Discovery year
  2004-02-11
• Entrez gene record
  158521
• Pubmed identfication
  • 12601173
• RefSeq identity
  • NM_152578
• VEGA ID
  OTTHUMG00000022608
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:25674
• Gene
  MEAF6
• Long gene name
  MYST/Esa1 associated factor 6
• Synonyms gene
  • C1orf149
• Synonyms gene name
  • chromosome 1 open reading frame 149
  • MYST/Esa1-associated factor 6
• Synonyms
  • NY-SAR-91
  • FLJ11730
  • Eaf6
  • CENP-28
• Synonyms name
  • Esa1p-associated factor 6 homolog (S. cerevisiae)
  • centromere protein 28
• GenBank acession
  • BC016328
• Locus
  1p34.3
• Discovery year
  2005-07-13
• Entrez gene record
  64769
• Pubmed identfication
  • 8619474
  • 9110174
  • 12963728
  • 14966270
  • 16387653
• RefSeq identity
  • NM_022756
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000004223

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