TGX-221

Alternative_name

(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one
Description

Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase β (IC₅₀ = 5 nM for p110β). Inhibits other PI3K isoforms at higher concentrations (IC₅₀ = 0.1 µM for p110δ, 5 µM for p110⍺, and 3.5 µM for p110ɣ).
CAS Number

663619-89-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₁H₂₄N₄O₂
Molecular Weight

364.44
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Handling

Protect from air and light
Tag Line

A potent inhibitor of PI 3-kinase β
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

48 months
MDL Number

MFCD11113209
PubChem CID

9907093
PubChem CID Link
SMILES

CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4
InChi

InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3
InChi Key

CPRAGQJXBLMUEL-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes