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Also known as
Chromogranin A
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Other names
chromogranin-A isoform 1 preproprotein; Chromogranin-A; chromogranin-A; SP-I; catestatin; chromofungin; pituitary secretory protein I; parathyroid secretory protein 1; betagranin (N-terminal fragment of chromogranin A); chromogranin A (parathyroid secretory protein 1); Pituitary secretory protein I; SP-I
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
CHGA
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Gene name synonims
N/A
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Other gene names
CHGA; CHGA; CGA; CgA; SP-I
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG1, kappa
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Clone
SPM339
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Host organism
Mouse (Mus musculus)
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Species reactivity
Human (Homo sapiens), Monkey, Pig, Mouse (Mus musculus), Rat (Rattus norvegicus). Does not react with guinea pig, sheep and Rabbit (Oryctolagus cuniculus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
N/A
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Form Appearance
N/A
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Concentration
N/A
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Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
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Tested applications
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
