GSK-2656157

• Catalog number
  9466-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone
• Description
  GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel of 300 kinases (IC₅₀>100 nM).
• CAS Number
  1337532-29-2
• Structure Available
  Yes
• Molecular Formula
  C₂₃H₂₁FN₆O
• Molecular Weight
  416.45
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selctive PERK (protein kinase R-like ER kinase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  53469059
• PubChem CID Link
• SMILES
  CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C
• InChi
  InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
• InChi Key
  PRWSIEBRGXYXAJ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GSK-2656157  
• Short name
  GSK-2656157
• Alternative name
  GSK-2656157

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