TG003

• Catalog number
  1905-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
• Description
  Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (Ki = 10 nM for mClk1/Sty; IC₅₀ = 20 nM, 200 nM, >10 µM, and 15 nM for mClk1, mClk2, mClk3, and mClk4, respectively). Recently, it has been shown that TG003 promotes the skipping of exon 31 in the endogenous dystrophin gene in a dose-dependent manner and increases the production of the dystrophin protein.
• CAS Number
  300801-52-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₃H₁₅NO₂S
• Molecular Weight
  249.33
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00624584
• PubChem CID
  647991
• PubChem CID Link
• SMILES
  CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C
• InChi
  InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3
• InChi Key
  BGVLELSCIHASRV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TG003  
• Short name
  TG003
• Alternative name
  TG003

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