SH-4-54

• Catalog number
  B1637-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  SH-4-54; SH454; SH 4 54; SH4-54; SH-454; 4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
• Description
  SH-4-54 is a most potent, small molecule, non-phosphorylated STAT3 inhibitor, strongly binds to STAT3 protein (KD = 300 nM), is selective for STAT3 over STAT1.
• CAS Number
  1456632-40-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₉H₂₇F₅N₂O₅S
• Molecular Weight
  610.59
• Cell Permeable
  Yes
• Purity
  >98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A most potent, small molecule, non-phosphorylated STAT3 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD28143917
• PubChem CID
  72188643
• PubChem CID Link
• SMILES
  CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
• InChi
  1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)
• InChi Key
  VFPYGNNOSJWBHF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SH-4-54  
• Gene symbol
  IGHV3-54, IGLV10-54, RNU6-54P, IFIT2, MIR1302-4, PIRC18, PIRC16, SNORD114-4
• Short name
  SH-4-54
• Alternative name
  SH-4-54

Gene info

• Identity
  HGNC:5611
• Gene
  IGHV3-54
• Long gene name
  immunoglobulin heavy variable 3-54 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-54
  • immunoglobulin heavy variable 3-54 pseudogene
• GenBank acession
  • M99680
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28419
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151962

Gene info

• Identity
  HGNC:5884
• Gene
  IGLV10-54
• Long gene name
  immunoglobulin lambda variable 10-54
• GenBank acession
  • Z73676
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28772
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000150993

Gene info

• Identity
  HGNC:42544
• Gene
  RNU6-54P
• Long gene name
  RNA, U6 small nuclear 54, pseudogene
• Synonyms gene
  • RNU6-54
• Synonyms gene name
  • RNA, U6 small nuclear 54
• Locus
  13q21.33
• Discovery year
  2011-08-08
• Entrez gene record
  106478986

Gene info

• Identity
  HGNC:5409
• Gene
  IFIT2
• Long gene name
  interferon induced protein with tetratricopeptide repeats 2
• Synonyms gene
  • IFI54
  • G10P2
• Synonyms gene name
  • interferon-induced protein with tetratricopeptide repeats 2
• Synonyms
  • IFI-54
  • ISG-54K
  • ISG-54
  • cig42
  • GARG-39
• GenBank acession
  • M14660
• Locus
  10q23.31
• Discovery year
  1989-06-06
• Entrez gene record
  3433
• Pubmed identfication
  • 3175763
  • 3360121
• RefSeq identity
  • NM_001547
• Classification
  • Tetratricopeptide repeat domain containing
• VEGA ID
  OTTHUMG00000018707

Gene info

• Identity
  HGNC:35296
• Gene
  MIR1302-4
• Long gene name
  microRNA 1302-4
• Synonyms gene
  • MIRN1302-4
• Synonyms
  • hsa-mir-1302-4
• Locus
  2q33.3
• Discovery year
  2008-11-03
• Entrez gene record
  100302130
• RefSeq identity
  • NR_031633
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37522
• Gene
  PIRC18
• Long gene name
  piwi-interacting RNA cluster 18
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313906
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37520
• Gene
  PIRC16
• Long gene name
  piwi-interacting RNA cluster 16
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313849
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32992
• Gene
  SNORD114-4
• Long gene name
  small nucleolar RNA, C/D box 114-4
• Synonyms
  • 14q(II-4)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767580
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003196.1
• Classification
  • Small nucleolar RNAs, C/D box

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