anti- BCR antibody

• Catalog number
  FNab00854
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
• Immunogen
  breakpoint cluster region
• Synonyms
  BCR1, D22S11
• Calculated MW
  150 kDa
• Uniprot ID
  P11274
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
• Image1
  Immunohistochemistry of paraffin-embedded human skin slide using FNab00854( BCR Antibody) at dilution of 1:50
• Image4
  Y79 cells were subjected to SDS PAGE followed by western blot with FNab00854(BCR antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BCR  
• Gene symbol
  BCRP1, BCRP2, BCRP4, BCR
• Short name
  anti- BCR antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- BCR (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:39073
• Gene
  BCRP1
• Long gene name
  BCR pseudogene 1
• Synonyms gene name
  • breakpoint cluster region pseudogene 1
• Synonyms
  • BCR-1
• Locus
  22q11.23
• Discovery year
  2010-09-30
• Entrez gene record
  644079
• Pubmed identfication
  • 3267213
• RefSeq identity
  • NG_009423
• VEGA ID
  OTTHUMG00000150768

Gene info

• Identity
  HGNC:1015
• Gene
  BCRP2
• Long gene name
  BCR pseudogene 2
• Synonyms gene
  • BCR2
  • BCRL2
• Synonyms gene name
  • breakpoint cluster region-like 2
  • breakpoint cluster region pseudogene 2
• Synonyms
  • BCR-2
• Locus
  22q11.21
• Discovery year
  2001-06-22
• Entrez gene record
  400892
• Pubmed identfication
  • 3267213
• RefSeq identity
  • NG_007131
• VEGA ID
  OTTHUMG00000150627

Gene info

• Identity
  HGNC:1017
• Gene
  BCRP4
• Long gene name
  BCR pseudogene 4
• Synonyms gene
  • BCR4
  • BCRL4
• Synonyms gene name
  • breakpoint cluster region-like 4
  • breakpoint cluster region pseudogene 4
• Synonyms
  • BCR-4
• GenBank acession
  • D87002
• Locus
  22q11.22
• Discovery year
  2001-06-22
• Entrez gene record
  616
• Pubmed identfication
  • 9074928
• RefSeq identity
  • NG_000002
• VEGA ID
  OTTHUMG00000151175

Gene info

• Identity
  HGNC:1014
• Gene
  BCR
• Long gene name
  BCR activator of RhoGEF and GTPase
• Synonyms gene
  • D22S11
  • BCR1
• Synonyms gene name
  • breakpoint cluster region
  • BCR, RhoGEF and GTPase activating protein
• Synonyms
  • D22S662
  • CML
  • PHL
  • ALL
• Locus
  22q11.23
• Discovery year
  1986-01-01
• Entrez gene record
  613
• Pubmed identfication
  • 1657398
  • 18070886
• RefSeq identity
  • NM_004327
• Classification
  • C2 domain containing
  • My-T-BRC complex
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000150655
• Locus Specific Databases
  • LRG_1112

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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