Jervine

• Catalog number
  2357-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1­1bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexad­ecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H­-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1­H)-one
• Description
  Cell-permeable. Structurally similar to cyclopamine (Cat. No. 1578). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine (Cat. No. 1893) is a useful negative control.
• CAS Number
  469-59-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₉NO₃
• Molecular Weight
  425.6
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (5 mg/ml) or EtOH (10 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A sonic hedgehog (Shh) pathway inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD01684066
• PubChem CID
  10098
• PubChem CID Link
• SMILES
  CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1
• InChi
  InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
• InChi Key
  CLEXYFLHGFJONT-DNMILWOZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Jervine  
• Short name
  Jervine
• Alternative name
  Jervine

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