Galiellactone

• Catalog number
  2623-500
• Price
  Please ask
• Size
  500 ug

• Alternative_name
  (7bS)-​5,​5aR,​6,​7,​7aR,​7b-​hexahydro-​7b-​hydroxy-​4S-​methyl-​indeno[1,​7-​bc]furan-​2(4H)-​one; NSC645020, NSC-645020
• Description
  Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC₅₀ = 0.25-0.5 μM). The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor.  At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.
• CAS Number
  133613-71-5
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₁H₁₄O₃
• Molecular Weight
  194.23
• Cell Permeable
  Yes
• Purity
  >95%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A STAT3 inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  6711856
• PubChem CID Link
• SMILES
  CC1CC2CCC3C2(C(=C1)C(=O)O3)O
• InChi
  InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m1/s1
• InChi Key
  SOIISBQQYAGDKM-VFYMIVFZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Galiellactone  
• Short name
  Galiellactone
• Alternative name
  Galiellactone

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