Elesclomol (STA-4783)

Alternative_name

N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; STA4783
Description

Elesclomol is a novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. The mechanism underlying the proapoptotic activity of elesclomol is through the induction of ROS (reactive oxygen species) and oxidative stress. Elesclomol rapidly induces ROS in cancer cells, generating a transcription profile characteristic of an oxidative stress response.
CAS Number

488832-69-5
Structure Available

Yes
Molecular Formula

C₁₉H₂₀N₄O₂S₂
Molecular Weight

400.52
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO ( >20 mg/ml)
Handling

Protect from air and light
Tag Line

A novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

300471
PubChem CID Link
SMILES

CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2
InChi

InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)
InChi Key

BKJIXTWSNXCKJH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes