NSC-687852

• Catalog number
  2021-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15
• Description
  Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
• CAS Number
  1009817-63-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₁₇N₃O₆
• Molecular Weight
  419.39
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (35 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent ubiquitin C-terminal hydrolase 5 (UCHL5) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  5351435
• PubChem CID Link
• SMILES
  C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
• InChi
  InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22 (27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+, 18-12+
• InChi Key
  GFARQYQBWJLZMW-JYFOCSDGSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NSC-687852  
• Short name
  NSC-687852
• Alternative name
  NSC-687852

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