NU6102
-
Catalog number2313-1
-
PricePlease ask
-
Size1 mg
-
-
Alternative_nameO6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine; 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-benzenesulfonamide
-
DescriptionA potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC₅₀ = 1.6 μM), DYRK1A (IC₅₀ = 0.9 μM), PDK1 (IC₅₀ = 0.8 μM) and ROCK-II (IC₅₀ = 0.6 μM). Inhibits cell growth.
-
CAS Number444722-95-6
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₁₈H₂₂N₆O₃S
-
Molecular Weight402.47
-
Cell PermeableYes
-
Purity≥98% by NMR
-
SolubilitiesDMSO
-
HandlingProtect from air and light
-
Tag LineA potent CDK1 and CDK2 inhibitor
-
Storage Condition-20 ̊C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
PubChem CID4566
-
SMILESC1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N
-
InChiInChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24)
-
InChi KeyOWXORKPNCHJYOF-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Gene target
-
Short nameNU6102
-
Alternative nameNU6102
-