Apoptosis inhibitor[Apoptosis inhibitor]

Products_type

Biochemical
Description

This 1 is suited for programmed cell-death studies. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

inhibitor[ inhibitor]
Gene symbol

PI15, TFPI, SPINK2
Short name

Apoptosis inhibitor[Apoptosis inhibitor]
Technique

apoptosis, apoptosis pathway
Alternative name

programmed cellular destruction suppressor[programmed cellular destruction suppressor]
Alternative technique

celldeath

Identity

HGNC:11760
Gene

TFPI
Long gene name

tissue factor pathway inhibitor
Synonyms gene
- LACI
Synonyms gene name
- tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Synonyms
- EPI
- TFI
- TFPI1
Synonyms name
- extrinsic pathway inhibitor
Locus

2q32.1
Discovery year

1991-06-03
Entrez gene record

7035
Pubmed identfication
- 1993173
RefSeq identity
- NM_006287
VEGA ID

OTTHUMG00000132634
Locus Specific Databases
- LRG_604

Identity

HGNC:11245
Gene

SPINK2
Long gene name

serine peptidase inhibitor Kazal type 2
Synonyms gene name
- serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
Synonyms
- HUSI-II
Synonyms name
- acrosin-trypsin inhibitor
GenBank acession
- BC022514
Locus

4q12
Discovery year

1993-12-01
Entrez gene record

6691
Pubmed identfication
- 8428671
RefSeq identity
- NM_021114
Classification
- Serine peptidase inhibitors, Kazal type
VEGA ID

OTTHUMG00000128769