UNC0646

• Catalog number
  2606-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-​(1-​cyclohexyl-​4-​piperidinyl)-​2-​[hexahydro-​4-​(1-​methylethyl)-​1H-​1,​4-​diazepin-​1-​yl]-​6-​methoxy-​7-​[3-​(1-​piperidinyl)propoxy]-​4-​quinazolinamine
• Description
  UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line.
• CAS Number
  1320288-17-2
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₃₆H₅₉N₇O₂
• Molecular Weight
  621.9
• Cell Permeable
  Yes
• Purity
  >98% by HPLC
• Solubilities
  DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent G9a inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  53315882
• PubChem CID Link
• SMILES
  CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6
• InChi
  InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)
• InChi Key
  OUKWLRHRXOPODD-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  UNC0646  
• Short name
  UNC0646
• Alternative name
  UNC0646

Product images

Similar products