EXOSC10/PMSCL2 Antibody

• Catalog number
  bs-13120R
• Price
  Please ask
• Size
  0.1ml

• Long name
  EXOSC10/PMSCL2 Primary Polyclonal Antibody
• Also known as
  EXOSC10/PMSCL2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  EXOSC10/PMSCL2
• Specificity
  This is a highly specific antibody against EXOSC10/PMSCL2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
• Gene ID number
  5394
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3’-5’ enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Autoantigen PM/Scl 2; Exosc10; Exosome component 10; EXOSX_HUMAN; P100 polymyositis scleroderma overlap syndrome associated autoantigen; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM Scl; PM/Scl 100; PM/Scl-100; PMSCL; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2 100 kDa; Polymyositis/scleroderma autoantigen 2; RRP6; Rrp6p.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  EXOSC10/PMSCL2  
• Gene symbol
  EXOSC10-AS1, EXOSC10
• Short name
  Anti-EXOSC10/PMSCL2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  EXOSC10/PMSCL2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40456
• Gene
  EXOSC10-AS1
• Long gene name
  EXOSC10 antisense RNA 1
• Locus
  1p36.22
• Discovery year
  2018-09-26
• Entrez gene record
  105376736
• RefSeq identity
  • NR_135061
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:9138
• Gene
  EXOSC10
• Long gene name
  exosome component 10
• Synonyms gene
  • PMSCL2
• Synonyms gene name
  • polymyositis/scleroderma autoantigen 2, 100kDa
• Synonyms
  • PM-Scl
  • PM/Scl-100
  • Rrp6p
  • RRP6
  • p2
  • p3
  • p4
• Synonyms name
  • polymyositis/scleroderma autoantigen 2 (100kD)
• GenBank acession
  • BC073788
• Locus
  1p36.22
• Discovery year
  1994-09-19
• Entrez gene record
  5394
• Pubmed identfication
  • 1383382
  • 1644924
• RefSeq identity
  • NM_001001998
• Classification
  • Exosome complex
• VEGA ID
  OTTHUMG00000002123

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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