Crizotinib

• Catalog number
  1934-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
• Description
  A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and survival of cell lines dependent upon c-Met or ALK enzymatic activity.
• CAS Number
  877399-52-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₂Cl₂FN₅O
• Molecular Weight
  450.34
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent c-Met and ALK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD12407409
• PubChem CID
  11626560
• PubChem CID Link
• SMILES
  CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
• InChi
  InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
• InChi Key
  KTEIFNKAUNYNJU-GFCCVEGCSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Crizotinib  
• Short name
  Crizotinib
• Alternative name
  Crizotinib

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