Oncostatin M, human recombinant
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Catalog number
4466-1000
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Price
Please ask
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Size
1 mg
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Synonyms
OSM, MGC20461, Oncostatin M.
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Alternative_names
OSM, MGC20461, Oncostatin M.
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Description
A pleiotropic cytokine important in liver development, haematopoeisis, inflammation and possibly CNS development
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Recombinant
Yes
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Source
E. coli
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Purity by SDS PAGE
≥98%
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Assay
SDS-PAGE
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Purity
≥98%
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Biological activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 5 x 10⁵ units/mg.
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Molecular Weight
26.0 kDa
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Storage Temp
-20°C
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Shipping
Gel pack
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Shelf Life
12 months
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Appearance
Lyophilized protein
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Physical form description
Sterile filtered and lyophilized with no additives
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Reconstitution Instructions
Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
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Background Information
Oncostatin M (OSM) is an important growth regulating cytokine that affects, variably, a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and other cellos, but augments the growth of normal fibroblasts, AIDs-related Kaposi sarcoma cells, and certain other cells. Recombinant Human Oncostatin M is a 26 kDa protein containing 227 amino acid residues.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
OSMR, OSM, IL6STP1
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Short name
Oncostatin M, recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Oncostatin M, H. sapiens Rec.
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
oncostatin M receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1999-02-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fibronectin type III domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
oncostatin M
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Synonyms
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GenBank acession
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Locus
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Discovery year
1992-07-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukin 6 type cytokine family
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VEGA ID
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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