mTOR Inhibitor, WYE-132
-
Catalog number2256-500
-
PricePlease ask
-
Size500 ug
-
-
Alternative_name1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea; WYE-125132
-
DescriptionCell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo.
-
CAS Number1144068-46-1
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₇H₃₃N₇O
-
Molecular Weight519.6
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (50 mg/ml)
-
HandlingProtect from light and moisture
-
Tag LineA sub-nanomolar potent mTOR inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life24 months
-
MDL NumberMFCD16038851
-
PubChem CID25260757
-
SMILESCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
-
InChiInChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
-
InChi KeyQLHHRYZMBGPBJG-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbolMRPS16, MIR132, TRERF1
-
Short namemTOR Inhibitor, WYE-132
-
Alternative nameMammalian target on rapamycin suppressor, WYE-132
-
Alternative to gene targetmechanistic target of rapamycin (serine/threonine kinase), FRAP and FRAP1 and FRAP2 and RAFT1 and RAPT1, MTOR and IDBG-89258 and ENSG00000198793 and 2475, transferase activity, nuclei, Mtor and IDBG-204403 and ENSMUSG00000028991 and 56717, MTOR and IDBG-632731 and ENSBTAG00000015325 and 100139219
-
Gene info
-
Identity
-
Gene
-
Long gene namemitochondrial ribosomal protein S16
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2001-02-28
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Mitochondrial ribosomal proteins
- Small subunit mitochondrial ribosomal proteins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 132
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR132/212 family
Gene info
-
Identity
-
Gene
-
Long gene nametranscriptional regulating factor 1
-
Synonyms gene
-
Synonyms gene name
- breast cancer anti-estrogen resistance 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-11-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Myb/SANT domain containing
-
VEGA ID